Set sail from the South.

Bring the kids, as theres entertainment and dedicated spaces for tweens and little ones, too.

The mighty Mississippi is calling your name on this 8-day journey from New Orleans to Memphis.

Giant cruise ship leaves PortMiami

Credit:Getty Images

MSCa Swiss-Italian company thats the worlds third-largest cruise brandsails from here, offering a few Caribbean options.

Even though this trip begins and ends in the U.S., you will need a passport to book.